宝丽乐是用食物原料在水中配成的保健品。它是特别设计成能连接到维生素D受体，并能替代由太
阳光产生的1.25 - 二羟基维生素D3。在人类研究中，宝丽乐(又名麦达迪哥)已被证明能治疗胰岛
素抵抗和糖尿病（一型和二型），增加维生素C和脂联素，降低血压，蛋白质氧化，NF-κB蛋白，
TNF蛋白和ICAM-1，并能调节血糖，VLDL（极低密度脂），C-反应蛋白，一氧化氮，白蛋白/球蛋
白比率，谷胱甘肽，PAI-1和MCP-1。因此，直接或间接宝丽乐可以帮助治疗或预防有关于这些维 生素，蛋白质和生物标志物失调而引起
的疾病。
Polilex is made from food ingredients that are formulated in water. It is designed to
bind to Vitamin D receptors and serve as a substitute for 1.25-Dihydroxy-Vitamin
D3 which is endogenously produced by sunlight. In human studies, Polilex (aka
Water-Soluble Policosanol) has shown to be very effective in treating insulin
resistance and diabetes (types I & II), increasing vitamins C and
adiponectin levels, reducing blood pressure, protein oxidation, NF-κB protein,
TNF protein and ICAM-1 levels, and regulating blood sugar, VLDL (very low
density lipids), C-reactive protein, nitric oxide, albumin/globulin ratio,
glutathione, PAI-1, and MCP-1 levels. Therefore, directly or indirectly, Polilex
could help in treating or preventing diseases associated with an imbalance of
these vitamins, proteins and biomarkers.
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维生素
D
随着人体中的十万亿（10的13次方）细胞，我们有上万亿的VDR（维生素D受体)。因此，足够的维生素D对支持细胞健康和免疫功能是非常重要的。一个健康的免疫系统，能启动巨噬细胞和杀伤性T细胞去对抗及毁灭入侵的病毒。
Vitamin
D
Along
with the 10 trillion (10 to the 13 power) cells in a human body, there are
trillions of VDR (Vitamin D Receptors). Therefore sufficient Vitamin D is
essential to support healthy cell and immune functions. A healthy immune system
could activate microphages and killer T cells to defend against invading
viruses.
诺曼A.
在Annals of Nutrition & Metabolism 2012, 61(3):199-206年刊中发表
以下的图片，来显示维生素D对支持人体六大生理系统和身体健康的贡献和重要性。
Norman
A. published the following diagram in Annals of Nutrition & Metabolism,
2012;61(3):199-206 to demonstrate the contributions of Vitamin D to support the
six physiological systems and good health.
在人体内, 1.25 - 二羟基维生素D3影响超过2000个基因。在正常生理和环境的情况下，人体通 过紫外线和皮肤中的7 - 脱氢胆固醇接触, 可以产生足够的维生素D3，供应给体内的营养需求。 然而，在现代的生活方式和工作环境中，大多数的人都在室内装有空调的建筑物里工作，并没有 吸收到充足的紫外线。即使是在室外阳光下，很多人经常会戴帽子或用雨伞来遮挡阳光及避免日 晒。对于那些到喜欢日光浴或常到海滩上的人，他们适用的防晒霜也会阻止皮肤吸收足够的紫外 线。因此，缺乏维生素D已成为一种普遍的现代健康问题。如上面的图片所示, 和维生素D缺乏有 关的疾病的患病率, 也一直在上升。
宝丽乐的每个喷洒, 包含超过10的18次方的普利醇纳米粒子, 是专门设计来连接到VDR。因此，宝丽乐具有作为代替1,25 - 二羟基维生素D3，提供正常的生化细胞的功能，和助于治疗或预防维生素D缺乏相关的疾病的能力。
1,25-Dihydroxy-Vitamin D3 affects over 2000 genes in the human body. Under normal physiological and environmental circumstances, the human body can generate significant quantities of vitamin D3 to meet its nutritionally defined requirements via ultraviolet exposure of 7-dehydrocholesterol present in the skin. However, in modem life-style and work environment, most people are confined indoor in air conditioned buildings during working hours and do not have sufficient exposure to ultraviolet light. Even at outdoor, many people would wear hats or carry umbrellas to shield themselves from sunlight. And for those who like the beach and sun bathing, the sunscreen they apply would prevent them from absorbing UV B rays that produce Vitamin D. Therefore, Vitamin D deficiency has become a norm for the modern generation and the prevalence of Vitamin D deficiency associated diseases, as indicated in the above picture, has been on the rise.
Each spray of Polilex contains more than 10 to the 18th power of policosanol nanoparticles which are specially designed to bind to the VDR. Therefore, Polilex has the ability to serve as a substitute for 1,25-Dihydroxy-Vitamin D3, provide normal biochemical cell function, and help to treat or prevent diseases associated with Vitamin D deficiency.
维生素 C
如下图所示, 医学家已经证实，心脏疾病，胰岛素抵抗，糖尿病, scury和许多其他健康问题, 都是与血清维生素C过少有关。一般上口服的补充维生素C并不太有效，也不能改善血管内皮功能 障碍或胰岛素抵抗。
Vitamin C
Medical researchers have known that heart disease, insulin resistance, diabetes, scury and many other health problems are accompanied by a decrease in serum vitamin C. Unfortunately, orally administered supplemental vitamin C is found to be ineffective and does not improve endothelial dysfunction or insulin resistance.
宝丽乐具有提高血清维生素C, 降低胰岛素抵抗，改善糖尿病和其他相关联维生素C过少的健康问 题的能力.
在一个60周的研究中，14个病人（7男, 7女), 使用宝丽乐来治疗代谢综合征，平均维生素C的数量, 在第12周时增加了21％, 在第60周时增加了100％。
Polilex has the ability to increase serum vitamin C and reduce the risk for insulin resistance, diabetes and other health problems associated with a low level of vitamin C.
In a 60-week clinical study of 14 patients (7 males and 7 females) with Metabolic Syndrome treated with Water-Soluble Policosanol, the average vitamin C level increased by 21% at Week 12 and 100% at Week 60.
脂联素
脂连蛋白是一种蛋白质激素，功能在于调节一些代谢过程，包括葡萄糖调节和脂肪酸分解代谢。 与脂联素过少有相关的疾病是代谢综合征，2型糖尿病，肥胖症，冠心病，高血压，非酒精性脂肪 肝疾病和其他健康问题。
宝丽乐具有增加脂联素含量，从而降低代谢综合征，冠状动脉疾病和其他疾病的能力。
Adiponectin
Adiponectin is a protein hormone that modulates a number of metabolic processes including glucose regulating and fatty acid catabolism. Diseases associated with a decrease in Adiponectin are Metabolic Syndrome, type 2 diabetes, obesity, coronary artery disease, hypertension, non-alcoholic fatty liver disease and other health problems.
Polilex has the ability to increase the Adiponectin level and thus reduce the risk for metabolic syndrome, coronary artery disease and other diseases.
NF - KB
如下图所示, 医学家已经证实，NF-κB活化会牵涉到许多疾病，包括癌症，过敏症，心肌梗死， 1型和2型糖尿病，肥胖，高胆固醇血症，心脏疾病，中风，克罗恩病，脑血管动脉瘤，哮喘，囊 性纤维化，肾脏疾病，肝脏疾病，肠道疾病，皮肤疾病，结核病，关节炎，青光眼，阑尾炎，肠 疾病，艾滋病（HIV-1），自身免疫性疾病，狼疮，帕金森疾病，视网膜病，亨廷顿氏病，白内障 和其他炎性病症。例如，库马尔A等人, 在Journal of Molecular Medicine, 2004:82:434-448上 发表以下的图片:
NF - Kappa B
Medical researchers have known that the activation of NF-κB has been implicated in many diseases and disorders including cancer, allergies, myocardial infarction, type 1 and type 2 diabetes, obesity, hypercholesterolemia, heart disease, stroke, Crohn’s disease, cerebral aneurysm, asthma, cystic fibrosis, kidney disease, liver disease, gut disease, skin disease, tuberculosis, arthritis, glaucoma, appendicitis, bowel disease, AIDS (HIV-1), autoimmunity, lupus, Parkinson disease, retina disease, Huntington’s disease, cataracts, and many other inflammatory diseases and disorders. For example, Kumar A, et. Al., published the following diagram in Journal of Molecular Medicine, 2004:82:434-448.
宝丽乐具有抑制NF-κB活化的能力，因此它可以用来治疗或预防与NF-κB活化相关的疾病。
Polilex has the ability to inhibit the activation of NF-κB which can in turn treat or prevent diseases associated with NF-κB activation in the body.
TNF
Alpha
如下图所示,
医学家已经证实，TNF-α (肿瘤坏死因子) 能增进炎症反应，导致许多与自身免疫
性疾病（如多发性硬化，湿疹，风湿性关节炎，牛皮癣），神经系统疾病（如阿尔茨海默氏病， 癫痫，双相性精神障碍，抑郁症),
骨质疏松症，癌症，非酒精性脂肪肝疾病，代谢性疾病，心血 管疾病和肺部疾病。例如，AGGARWAL BB等人，在Blood, Jan
2012:100(3):651-665. 上发表以下 的图片:
TNF
Alpha
Medical
researchers have known that TNF alpha promotes the inflammatory response which
causes many of the clinical problems associated with autoimmune disorders (such
as multiple sclerosis, eczema, rheumatoid arthritis, psoriasis), neurologic
diseases (such as Alzheimer’s disease, epilepsy, bipolar disorder, depression),
osteoporosis, cancer, non-alcoholic fatty liver disease, metabolic diseases,
cardiovascular diseases and pulmonary diseases. For example, Aggarwal BB, et.
Al., published the following diagram in Blood, Jan
2012:100(3):651-665.
宝丽乐具有调节和降低TNFα含量的能力,
因此它可用来治疗或预防与TNFα过高有相关疾病。
Polilex has the ability to regulate and reduce the TNF alpha level which can in turn
treat or prevent diseases associated with elevated level of TNF alpha in the
body.
人类基因组
如下图所示,
医学家已经证实，在人类基因组中的DNA是组织成单位称为基因。该基因的排列方 式，是非常重要的。万一一个基因的构建基块出现了“拼写错误”,
就可能会导致疾病。
The
Human Genome
Medical
researchers have known that much of the DNA in the human genome is organized
into units called genes. The way the genes are arranged makes all the difference
- one building block “misspelled” in a gene can cause disease.
宝丽乐具有能力去活化位于在12号染色体的维生素D受体(VDR），以形成复合物去结合于DNA的激素反应元素。这导致到特定的基因产物被抑制，带来了所需要的生理变化,
去纠正缺陷的基因转录。
Polilex has the ability to activate the Vitamin D Receptor (VDR), encoded by the VDR
gene located on chromosome 12, to form a complex that binds to hormone response
elements on DNA. This results in expression or repression of specific gene
products and brings about the desired physiological changes and proper gene
transcription.
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